Analytic

We are familiar with all common in-vitro models for testing the permeation and penetration of pharmaceutical products. This includes the classic Franz cell, Ussing – chambers and the “Saarbrückener model”.

In this context we use the following tissues/membranes: human skin, pig skin, buccal mucosa (pig) and small intestinal mucosa (rat), artificial membranes, etc.

We gladly develop and establish customized models on request (alternative animal skins and special artificial membranes).

Tailored to your needs, we offer dissolution methods for various dosage forms using USP Apparatus I, II, IV and V. The media are of compendial grade.

Biorelevant media like FeSSIF/FaSSIF are also used to get deeper insight into the biopharmaceutical properties of your product.

In the field of particle characterization, we offer in addition to visualization by light microscopy two measuring methods for particle size determination. These are based on the dynamic (Zetasizer: 0.6 to 6 microns) and static (Mastersizer: up to 2000 microns) laser light scattering.

As further tools for powder characterization we have established methods for surface area and pore-distribution measurement by gas adsorption (BET) and determination of electrical particle charge (zeta potential).